COL4A1 and fetal vascular origins of schizencephaly

COL4A1 gene mutation – beyond a vascular syndrome

COL4A1 mutations have been associated with a variety of vascular abnormalities and disease manifestations, including porencephaly, infantile hemiparesis, intracerebral hemorrhage in neonates and children, intracerebral hemorrhage and cerebral small vessel disease in adulthood, intracranial aneurysms, and retinal arteriolar tortuosities [1]. The gene encodes for type IV collagen a1 that forms th...

Fetal origins of obesity.

The worldwide epidemic of obesity continues unabated. Obesity is notoriously difficult to treat, and, thus, prevention is critical. A new paradigm for prevention, which evolved from the notion that environmental factors in utero may influence lifelong health, has emerged in recent years. A large number of epidemiological studies have demonstrated a direct relationship between birth weight and B...

Fetal Origins and Parental Responses;

Schizencephaly. .

45 melanin, but also slow nail growth rate resulting in larger accumulation of the pigment. The presence of HHN neither correlates with degree of renal impairment nor with blood urea nitrogen or creatinine levels. HHN can be an important clue in making the diagnosis of renal disease. 3 0 year old male presented with history of generalised tonic clonic seizures since the age of 16 poorly control...

Fetal origins of adult disease

Several decades of research have demonstrated that significant contributions to risk of cardiovascular disease are made by adult lifestyle factors such as smoking, high consumption of saturated fats and salt, low levels of physical activity, and obesity. The more recent assertion that the risk of hypertension and coronary heart disease in adult life may be determined by an adverse environment b...